This Application Note describes how laser-based headspace inspection
detects vials having raised stopper issues. Experiments are described which demonstrate that the closure failure rate in a set of vials having raised stoppers is a probabilistic function of the stopper height. Inspection data from a commercial lyo batch suffering from raised stopper issues is also presented showing that quantifying the physical headspace conditions also enables science-based process troubleshooting and optimization.

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Other interesting topics

Download the Lighthouse Brochure

Download the White Paper: "Introduction to Laser-Based Headspace Inspection and the Application to 100% Container Closure Inspection of Sterile Pharmaceutical Containers"”

Download the Application Note “Stopper Pop-Up and the Effects on Container Closure of Sterile Vials”

Download the Application Note “In-process Monitoring of Headspace Oxygen Levels in Parenteral Containers"

Download the poster “Non-Destructive Monitoring of Oxygen in Pre-Filled Syringes”